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Sideritis galatica Bornm.: A source of multifunctional agents for the management of oxidative damage, Alzheimer's's and diabetes mellitus
Scopus
Toplam 132 atıf DOI
The antioxidant and enzyme inhibitory potential of different solvent extracts (petroleum ether, ethyl acetate, methanol and water) from Sideritis galatica were evaluated. Cholinesterase, α-amylase and α-glucosidase inhibitory activities of the extracts were tested by microtiter plate assays. Antioxidant abilities were tested using free radical scavenging (DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) and NO), reducing power (FRAP (ferric reducing antioxidant power) and CUPRAC (cupric reducing antioxidant capacity)), total antioxidant capacity and chelating assays. Methanol and water extracts showed higher phenolic content, DPPH and ABTS scavenging activity and reducing power activities, while the petroleum ether and ethyl acetate extract had the highest inhibition abilities on the enzymes. 18 phenolic components in these extracts were detected by using high performance liquid chromatography-diode array detector (HPLC-DAD). Results obtained in this work indicate that S. galatica may be useful as a source of natural agents for the management of oxidative process, Alzheimer's disease and type II diabetes.
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Natural two Taraxacum species effective against frameshift and base pair substitution mutations: Mutagenic, antimutagenic and antioxidant evaluation
Scopus
Havuzumuzda 2 atıf almış
Plant or plant products have gained increasing importance in pharmacology and food industries in recent years due to their lower toxicity and side effects. The genus Taraxacum belonging to Asteraceae family have been used in traditional medicine since ancient times. In this study, antioxidant, mutagenic and antimutagenic properties of two Taraxacum species namely T. mirabile and T. farinosum were investigated. Antioxidant properties were determined by different test systems including DPPH radical scavenging, reducing power (CUPRAC and FRAP assays) and phosphomolybdenum assays. Total phenolic and flavonoid contents were also reported. Mutagenic and anti-mutagenic activities were tested by Ames assay. It was seen that Taraxacum species have moderate antioxidant and antimutagenic activities ranging between moderate to strong. However, the species were found to be non-mutagenic. It was determined that total phenolic and flavonoid contents in T. mirabile (23.43 mgGAE/g extract and 4.58 mgRE/g extract) were higher than T. farinosum (17.54 mgGAE/g extract and 3.37 mgRE/g extract).
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Kurumlar (1)
Selçuk Üniversitesi
Selçuklu, Turkey