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Sideritis galatica Bornm.: A source of multifunctional agents for the management of oxidative damage, Alzheimer's's and diabetes mellitus
Scopus
Toplam 130 atıf DOI
The antioxidant and enzyme inhibitory potential of different solvent extracts (petroleum ether, ethyl acetate, methanol and water) from Sideritis galatica were evaluated. Cholinesterase, α-amylase and α-glucosidase inhibitory activities of the extracts were tested by microtiter plate assays. Antioxidant abilities were tested using free radical scavenging (DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) and NO), reducing power (FRAP (ferric reducing antioxidant power) and CUPRAC (cupric reducing antioxidant capacity)), total antioxidant capacity and chelating assays. Methanol and water extracts showed higher phenolic content, DPPH and ABTS scavenging activity and reducing power activities, while the petroleum ether and ethyl acetate extract had the highest inhibition abilities on the enzymes. 18 phenolic components in these extracts were detected by using high performance liquid chromatography-diode array detector (HPLC-DAD). Results obtained in this work indicate that S. galatica may be useful as a source of natural agents for the management of oxidative process, Alzheimer's disease and type II diabetes.
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Atıf Yapan Yayın
Amylase, glucosidase, tyrosinase, and cholinesterases inhibitory, antioxidant effects, and GC-MS analysis of wild mint (Mentha longifolia var. calliantha) essential oil: A natural remedy
Scopus
Havuzumuzda 87 atıf almış
Introduction: Mint is used as a herbal tea, in food additives, and as a traditional medicine all around the world. They are popular functional foods and natural remedies. A comprehensive bioactivity evaluation was performed on wild mint essential oil to shed light on its health beneficial effects and therapeutic potential as a very popular herb. Methods: The chemical composition of essential oil of wild mint (Mentha longifolia var. calliantha (Stapf) Briq.) was determined together with its antioxidant and enzyme inhibitory potential linked to Alzheimer's disease, diabetes mellitus, and skin disorders. Six different methods were employed to examine antioxidant ability, including; DPPH, ABTS, CUPRAC, FRAP, metal chelating, and Molybdenum total antioxidant assays. Results: Findings showed that 1,8-cineol (33.5%), linalool (15.1%), menthone (12.9%), and trans-piperitone oxide (12.6%) are the main volatile compounds of the plant. The essential oil exhibited promising antiradical activity (5.8 and 9.1 mmol TEs/g oil in DPPH and ABTS assays, respectively) and reducing power (102 and 337 mmol TEs/g oil in FRAP and CUPRAC assays, respectively). Moreover, remarkable antidiabetic, anticholinesterase, and antityrosinase effects were recorded for the mint oil. Conclusion: Wild mint essential oil has valuable bioactive constituents and great potential for uses in food, pharmaceutical, and cosmeceuticals industries.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
Biotechnology Research Center,Tabriz
Tabriz, Iran
Imam Khomeini International University
Qazvin, Iran
Maragheh University of Medical Sciences
Maragheh, Iran
Selçuk Üniversitesi
Selçuklu, Turkey
Shahid Beheshti University
Tehran, Iran