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A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems
Scopus
Toplam 133 atıf DOI
Asphodeline species are traditionally used as food and medicines. The different extracts (acetone, methanol and water) from different parts (stem, root, seed and leaf) of Asphodeline anatolica were screened for inhibitory potentials on cholinesterase, tyrosinase, α-amylase and α-glucosidase. Enzyme inhibitory effects were investigated by using microplate reader. All studied extracts exhibited remarkable inhibitory effects on the tested enzymes. Generally, acetone and methanol extracts have higher potentials than water extracts. Also, the enzyme inhibitory activities of the extracts varied significantly according to the plant parts as well as the solvent used. R-Met (7.42. mgGALAEs/g extract) and St-Ac (10.74. mgGALAEs/g extract) had the highest acetylcholinesterase and butrylcholinesterase inhibitory activity, respectively. R-Met (22.48. mgKAEs/g extract) exhibited the strongest tyrosinase inhibitory effects, while Se-Ac had the most potent activity on both α-amylase (2.53. mmolACAEs/g extract) and α-glucosidase (6.70. mmolACAEs/g extract). The results suggested that the A. anatolica extract may be useful for food and medicinal applications.
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Ajuga chamaecistus subsp. scoparia (Boiss.) Rech.f.: A new source of phytochemicals for antidiabetic, skin-care, and neuroprotective uses
Scopus
Havuzumuzda 54 atıf almış
The genus Ajuga is used traditionally as food and medicine. The aim of this study was to investigate the antidiabetic, anti-Alzheimer's diseases, skin-protective, and antioxidant activities of essential oil and extracts of Ajuga chamaecistus subsp. scoparia (Boiss.) Rech.f., together with the identification of their chemical composition. The 1,1-diphenyl-2-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazloine-6-sulfonic acid) radical cation scavenging activity, metal chelating activity, reducing power, content of total bioactive compounds, general toxicity, and enzyme inhibitory potential of essential oil, ethanol extract, and water decoction of the plant were evaluated. Phenolics profile of the extracts was analyzed using the reverse-phase high-performance liquid chromatography with diode array detector and the chemical composition of the essential oil was determined using the gas chromatography and gas chromatography–mass spectroscopy techniques. The essential oil could significantly inhibit the activity of α-glucosidase (4.3 mmol Acarbose equivalents/g), α-amylase (2.8 mmol Acarbose equivalents/g), acetylcholinesterase (1.96 mg gallic acid equivalents/g), butyrylcholinesterase (2.2 mg gallic acid equivalents/g), and tyrosinase (36 mg kojic acid equivalents/g) while ethanol and water extracts showed moderate enzyme inhibitory activity. Furthermore, essential oil had the strongest antioxidant capacity in the 1,1-diphenyl-2-picrylhydrazyl scavenging, 2,2-azino-bis (3-ethylbenzothiazloine-6-sulfonic acid) scavenging, cupric reducing antioxidant capacity, ferric reducing antioxidant power, and metal chelating assays. Spathulenol (18.0%), thymol (15.1%), octen-3-ol (14.3%), and linalool oxide (11.2%) were identified as major constituents in the essential oil. Quantitative high-performance liquid chromatography analysis indicated that p-coumaric acid, gallic acid, and ferulic acid are the main phenolic compounds in this plant. The results suggested that Ajuga chamaecistus could be useful for several applications as functional foods, cosmetics, and pharmaceuticals.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
Biotechnology Research Center,Tabriz
Tabriz, Iran
Research Center for Pharmaceutical Nanotechnology
Tabriz, Iran
Selçuk Üniversitesi
Selçuklu, Turkey
Süleyman Demirel Üniversitesi
Isparta, Turkey
Urmia University of Medical Sciences
Urmia, Iran