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A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems
Scopus
Toplam 133 atıf DOI
Asphodeline species are traditionally used as food and medicines. The different extracts (acetone, methanol and water) from different parts (stem, root, seed and leaf) of Asphodeline anatolica were screened for inhibitory potentials on cholinesterase, tyrosinase, α-amylase and α-glucosidase. Enzyme inhibitory effects were investigated by using microplate reader. All studied extracts exhibited remarkable inhibitory effects on the tested enzymes. Generally, acetone and methanol extracts have higher potentials than water extracts. Also, the enzyme inhibitory activities of the extracts varied significantly according to the plant parts as well as the solvent used. R-Met (7.42. mgGALAEs/g extract) and St-Ac (10.74. mgGALAEs/g extract) had the highest acetylcholinesterase and butrylcholinesterase inhibitory activity, respectively. R-Met (22.48. mgKAEs/g extract) exhibited the strongest tyrosinase inhibitory effects, while Se-Ac had the most potent activity on both α-amylase (2.53. mmolACAEs/g extract) and α-glucosidase (6.70. mmolACAEs/g extract). The results suggested that the A. anatolica extract may be useful for food and medicinal applications.
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Antioxidant and enzyme inhibitory activities of disodium rabdosiin isolated from Alkanna sfikasiana Tan, Vold and Strid
Scopus
Havuzumuzda Open Access 21 atıf almış
Alkanna sfikasiana Tan, Vold and Strid is an endemic Greek species of Boraginaceae family. From the roots, the new natural product disodium rabdosiin (1) along with rosmarinic acid (2) were isolated from the methanolic extract and lanosta-7,24-dien-3β-ol (3) and linoleic acid (4) from the cyclohexane extract. From the methanolic extract of the aerial parts two flavonoids quercetin 3-Ο-β-D-glucoside (5) and quercetin 3-Ο-β-D-rutinoside (6) were isolated. The antioxidant properties exhibited good radical scavenging activity (96.00 mgTE/g for DPPH; 441.97 mgTE/g for ABTS) and reducing power ability (720.81 mgTE/g for CUPRAC and 413.94 mgTE/g for FRAP) for the new compound 1. Enzyme inhibitory activity has been also evaluated, showing inhibitory effects on AChE (4.32 mgGALAE/g), BChE (3.63 mgGALAE/g) and α-amylase (3.83 mmolACAE/g). Consequently, our study could provide a potential candidate for developing novel phyto-pharmaceutics and it could be considered a new starting point on the studied species.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
National & Kapodistrian University of Athens, School of Health Sciences
Athens, Greece
Selçuk Üniversitesi
Selçuklu, Turkey