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A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems
Scopus
Toplam 133 atıf DOI
Asphodeline species are traditionally used as food and medicines. The different extracts (acetone, methanol and water) from different parts (stem, root, seed and leaf) of Asphodeline anatolica were screened for inhibitory potentials on cholinesterase, tyrosinase, α-amylase and α-glucosidase. Enzyme inhibitory effects were investigated by using microplate reader. All studied extracts exhibited remarkable inhibitory effects on the tested enzymes. Generally, acetone and methanol extracts have higher potentials than water extracts. Also, the enzyme inhibitory activities of the extracts varied significantly according to the plant parts as well as the solvent used. R-Met (7.42. mgGALAEs/g extract) and St-Ac (10.74. mgGALAEs/g extract) had the highest acetylcholinesterase and butrylcholinesterase inhibitory activity, respectively. R-Met (22.48. mgKAEs/g extract) exhibited the strongest tyrosinase inhibitory effects, while Se-Ac had the most potent activity on both α-amylase (2.53. mmolACAEs/g extract) and α-glucosidase (6.70. mmolACAEs/g extract). The results suggested that the A. anatolica extract may be useful for food and medicinal applications.
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Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone
Scopus
Havuzumuzda 28 atıf almış
Silene viridiflora (Caryophyllaceae) has adaptogen, tonic, actoprotector and immunomodulator properties that are mainly attributed to ecdysteroids. The aim of the present study is to investigate the chemical constituents of essential oil as well as the 20-hydroxyecdysone content in the methanol extract S. viridiflora and its related biological activity. GC–MS analysis showed the essential oil of S. viridiflora to have a complex composition, which was dominated by methyl palmitate (8.05%), 3-hexen-1-ol (7.54%), 3-hexenyl benzoate (3.86%), β-myrcene (3.80%), 1,1-diethoxy-2-phenylethane (3.65%), hexahydrofarnesyl acetone (3.20%) and 4-terpineol (2.47%). A high performance thin-layer chromatography (HPTLC) method was developed to analyze the methanolic extracts of S. viridiflora and to quantify the main ecdysteroid, 20-hydroxyecdysone. Validation showed that the method was accurate over the entire calibration range and resulted in errors of less than 10% in the 100–815 μg/ml concentration range. Antioxidant and enzyme inhibitory potentials of methanol extract and individual compounds of S. viridiflora were evaluated. The results could provide a starting point for designing novel phyto-pharmaceuticals.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
BOKU University
Vienna, Austria
Selçuk Üniversitesi
Selçuklu, Turkey
S. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences
Tashkent, Uzbekistan