Kurumun Atıf Alan Makalesi
Atıf Alan Yayın
A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems
Scopus
Toplam 133 atıf DOI
Asphodeline species are traditionally used as food and medicines. The different extracts (acetone, methanol and water) from different parts (stem, root, seed and leaf) of Asphodeline anatolica were screened for inhibitory potentials on cholinesterase, tyrosinase, α-amylase and α-glucosidase. Enzyme inhibitory effects were investigated by using microplate reader. All studied extracts exhibited remarkable inhibitory effects on the tested enzymes. Generally, acetone and methanol extracts have higher potentials than water extracts. Also, the enzyme inhibitory activities of the extracts varied significantly according to the plant parts as well as the solvent used. R-Met (7.42. mgGALAEs/g extract) and St-Ac (10.74. mgGALAEs/g extract) had the highest acetylcholinesterase and butrylcholinesterase inhibitory activity, respectively. R-Met (22.48. mgKAEs/g extract) exhibited the strongest tyrosinase inhibitory effects, while Se-Ac had the most potent activity on both α-amylase (2.53. mmolACAEs/g extract) and α-glucosidase (6.70. mmolACAEs/g extract). The results suggested that the A. anatolica extract may be useful for food and medicinal applications.
Atıf Kaynağı
Atıf Yapan Yayın
Analysis of phytochemical composition and biological activities of Helichrysum pallasii (Sprengel) ledeb leaves
Scopus
Havuzumuzda Open Access 2 atıf almış
This study aimed at the investigation of in vitro biological activities (antioxidant and enzyme inhibition) and phytochemical composition of various extracts (ethanol maceration, aqueous infusion, and aqueous decoction) obtained from leaf organs of Helichrysum pallasii, which has been traditionally used as herbal tea and medicine in Eastern Anatolia. Experimental analysis showed that ethanol-based extract had higher total phenolic content (TPC: 103 mg GAE/gE) and showed superior antioxidant potentials (FRAP: 2205 μmol Fe2+/gE; ORAC: 2540 μmol Trolox Eq./gE; DPPH: IC50=0.58 mg/ml; CUPRAC: IC50=0.37 mg/ml; Phosphomolybdenum: IC50=1.34 mg/ml ve metal chelation: IC50=1.42 mg/ml) and enzyme inhibition (Acetylcholinesterase: IC50=1.49 mg/ml; Butyrylcholinesterase: IC50=1.98 mg/ml; Tyrosinase: IC50=0.68 mg/ml; Alpha-amylase: IC50=2.09 mg/ml; Alpha-glucosidase: IC50=0.51 mg/ml; and Pancreatic lipase: IC50=42.5 μg/ml) and contained higher amounts of phenolic (chlorogenic acid isomers and rutin) and fatty acid (palmitic, linoleic, and linolenic acids) compounds than traditional preparations (infusion and decoction). The current study's findings indicate that the leaves of the Helichrysum pallasii are a source of phytochemicals with strong antioxidant and enzyme inhibitory properties, implying that it could be a candidate for biotherapeutic agent research and development.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Hakkari Üniversitesi
Hakkari, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey
Van Yüzüncü Yıl Üniversitesi
Van, Turkey