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Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential
Scopus
Toplam 151 atıf DOI
In this study, the nutraceutical potential of Capparis spinosa L. for the treatment of hyperglycemic states has been thoroughly investigated. A series of in vivo and in vitro tests have been conducted on fresh leaf, buds and salty buds (24 h desalted) processed to dry powder. 60% MeOH/H2O extracts were obtained for HPLC analysis and for α-amylase and α-glucosidase inhibition tests. To estimate the in vivo anti-diabetic effect, dry powders of C. spinosa leaf and buds were orally administered to streptozocin-induced diabetic rats over a period of 28 days. At the end of the experiment, animals were sacrificed, blood taken for assessment of lipid profile and liver/kidney biochemistry while section of the pancreas, liver and kidneys were processed for general histology. Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection.
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Atıf Yapan Yayın
Pharmacological activities, chemical profile, and physicochemical properties of raw and commercial honey
Scopus
Havuzumuzda 45 atıf almış
This study was designed to evaluate and correlate the pharmacological, phytochemical, and physicochemical properties of raw unifloral Mauritian eucalyptus honey (EH) and a commercially available honey (CH). The pharmacological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity (MCF-7 and HeLa cell toxicity). The presence of phytochemicals including alkaloids, flavonoids, saponins, phenols, anthraquinones, and steroids were determined along with the total phenolic (TPC), total flavonoid (TFC), and tannin content (TC). Physicochemical properties including the pH, colour, total soluble solids, and density were also investigated. The results showed that EH displayed greater antibacterial, antioxidant, and anticancer activity against the MCF-7 cell line compared to CH, which also showed higher extracellular antimelanogenic activity. MH (IC50 = 532.75 μg/ml) displayed significantly greater scavenging activity than CH (IC50 = 647.6 μg/ml). To conclude, honey may be potentially exploited as complementary and alternative therapies for the management of infectious and chronic diseases.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Selçuk Üniversitesi
Selçuklu, Turkey
University of Mauritius
Reduit, Mauritius
University of Pretoria
Pretoria, South Africa