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Associations between chronotype, sleep quality, suicidality, and depressive symptoms in patients with major depression and healthy controls
Scopus
Toplam 168 atıf DOI
Research interest concerning associations between sleep characteristics and suicidality in psychopathology has been growing. However, possible linkages of suicidality to sleep characteristics in terms of sleep quality and chronotypes among depressive patients have not been well documented. In the current study, the authors investigated the possible effects of sleep quality and chronotype on the severity of depressive symptoms and suicide risk in patients with depressive disorder and healthy controls. The study was conducted on 80 patients clinically diagnosed with major depression and 80 healthy subjects who were demographically matched with the patient group. All participants completed a questionnaire package containing self-report measures, including the Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), MorningnessEveningness Questionnaire (MEQ), and Suicide Ideation Scale (SIS), and subjects were interviewed with the suicidality section of the Mini-International Neuropsychiatric Interview (MINI). Results are as follows: (a) logistic regression analyses revealed that poor sleep quality and depression symptom severity significantly predicted onset of major depression; (b) morningness-type circadian rhythm may play as a significant relief factor after onset of major depression; (c) sleep variables of chronotype and sleep quality did not significantly predict suicide ideation after controlling for depressive symptoms in the major depression group; and (d) suicide ideation and poor sleep quality were antecedents of depression symptom severity in patients with major depression, and in healthy controls. Findings are discussed under the theoretical assumptions concerning possible relations between chronotype, sleep quality, depression, and suicidality. © 2010 Informa Healthcare USA, Inc.
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Chronotype preference and circadian markers in children and adolescents with obsessive–compulsive disorder: A case–control study
Scopus
Havuzumuzda
Background Circadian rhythm disturbances have been implicated in several psychiatric disorders; however, circadian characteristics in pediatric obsessive–compulsive disorder (OCD) remain insufficiently investigated. Chronotype, reflecting individual differences in circadian timing, has been associated with both psychopathology and symptom severity in various psychiatric conditions. This study aimed to examine chronotype distribution in children and adolescents with OCD and to investigate the relationship between chronotype and OCD symptom severity using both psychometric assessments and biological circadian markers. Methods This cross-sectional clinical study included 29 children and adolescents diagnosed with OCD and 30 age- and sex-matched healthy controls. Psychiatric diagnoses were confirmed using the Kiddie Schedule for Affective Disorders and Schizophrenia – Present and Lifetime Version (K-SADS-PL). Chronotype was assessed using the Children's Chronotype Questionnaire (CCQ). OCD symptom severity was evaluated with the Children's Yale–Brown Obsessive–Compulsive Scale (CY-BOCS). Depression and anxiety symptoms were assessed using the Children's Depression Inventory (CDI) and the Screen for Child Anxiety Related Emotional Disorders (SCARED). Sleep disturbances were evaluated using the Sleep Disturbance Scale for Children (SDSC). Morning salivary melatonin and cortisol levels were measured as endogenous circadian markers. Results Evening chronotype was more frequent in the OCD group compared with healthy controls (p < 0.05). Within the OCD group, participants with evening chronotype showed significantly lower CY-BOCS scores compared with non-evening chronotypes (p < 0.05). Melatonin levels were significantly higher in the evening chronotype subgroup (p < 0.05), whereas cortisol levels did not differ significantly between chronotype groups (p > 0.05). Conclusions Children and adolescents with OCD appear more likely to exhibit evening chronotype characteristics. The association between chronotype and OCD severity suggests that circadian profiles may play a role in the clinical presentation of pediatric OCD. Considering chronotype characteristics during clinical assessment may contribute to a better understanding of circadian influences on OCD.
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Kurumlar (2)
Private Practice
Konya, Turkey
Selçuk Tip Fakültesi
Konya, Turkey