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Activity of Essential Oils and Individual Components against Acetyl-and Butyrylcholinesterase
Scopus
Open Access Toplam 174 atıf DOI
We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical fertilizers), two from Mentha piperita L. and M. spicata L. (organic fertilizer), two from Lavandula officinalis Chaix ex Villars (cultivated using organic and chemical fertilizers), two from Ocimum basilicum L. (green and purple-leaf varieties cultivated using only organic fertilizer), four from Origanum onites L., O. vulgare L., O. munitiflorum Hausskn., and O. majorana L. (cultivated using organic fertilizer), two from Salvia sclarea L. (organic and chemical fertilizers), one from S. officinalis L. (organic fertil-izer), and one from Satureja cuneifolia Ten. (organic fertilizer) by a spectrophotometric method of Ellman using ELISA microplate-reader at 1 mg/ml concentration. In addition, a number of single components widely encountered in most of the essential oils [y-terpinene, 4-allyl anisole, (-)-carvone, dihydrocarvone, (-)-phencone, cuminyl alcohol, cumol, 4-isopro-pyl benzaldehyde, trans-anethole, camphene, iso-borneol, (-)-borneol, L-bornyl acetate, 2-decanol, 2-heptanol, methyl-heptanol, farnesol, nerol, iso-pulegol, 1,8-cineole, citral, citronel-lal, citronellol, geraniol, linalool, α-pinene, β-pinene, piperitone, iso-menthone, menthofu-rane, linalyl oxide, linalyl ester, geranyl ester, carvacrol, thymol, menthol, vanilline, and eu-genol] was also screened for the same activity in the same manner. Almost all of the essential oils showed a very high inhibitory activity (over 80%) against both enzymes, whereas the single components were not as active as the essential oils. © 2008, Verlag der Zeitschrift für Naturforschung. All rights reserved.
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Chemical variability, pharmacological potential, multivariate and molecular docking analyses of essential oils obtained from four medicinal plants
Scopus
Havuzumuzda 29 atıf almış
Essential oils (EOs) hold tremendous medicinal attributes and are greatly exploited industrially worldwide. In the present study, the chemical composition of five EOs prepared from four aromatic plants were revealed together with their inhibitory activities against five key clinical enzymes (α-amylase, α-glucosidase, tyrosinase, acetyl- and butyryl-cholinesterase). Limonene (84.3%) and sabinene (38.1%) were the most dominant constituents present in Citrus aurantium fruit peel and leaf EOs respectively. Turmerone (31.4%), ar-turmerone (16.1%), and turmerol (14.6%) were the principal components identified in Curcuma longa rhizome EO. Additionally, Morinda citrifolia fruit EO was abundant in octanoic acid (78.9%), while carvacrol (17.9%), δ-3-carene (15.2%), and camphor (12.9%) were predominant in Plectranthus amboinicus EO. The investigated EOs were all active inhibitors of acetylcholinesterase, amylase, and tyrosinase. Morinda citrifolia and P. amboinicus EOs inhibited butyrylcholinesterase exclusively, while M. citrifolia and C. aurantium fruit peel EOs displayed inhibition against glucosidase as well. Due to strong interactions with their active sites, molecular docking showed turmerone followed by carvacrol to have the highest binding affinities with target enzymes. Moderate to strong antioxidant potential was also demonstrated by all EOs. However, P. amboinicus EO presented the most potent antioxidant capacity and contained the highest amount of phenolics, while M. citrifolia EO was the weakest among all. Besides, a strong positive correlation was noted between EOs’ antioxidant capacities and total phenolic content. With the exception of C. aurantium leaf and C. longa EOs which showed similar bioactivities and were grouped together, the other EOs were subdivided into distinct groups by principal component analysis. Altogether, this study highlighted interesting pharmacological properties of the investigated EOs that could serve as sources of bioactive ingredients with potential industrial applications.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Duy Tan University
Da Nang, Viet Nam
Salahaddin University-Erbil
Erbil, Iraq
Selçuk Üniversitesi
Selçuklu, Turkey
University of Mauritius
Reduit, Mauritius