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Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
Scopus
Open Access Toplam 182 atıf DOI
Goji (Lycium barbarum L.) leaves are emphasized as a functional tea or as dietary supplements. The phenolic compound profile, antioxidant, enzyme inhibitory, antimicrobial, and antimutagenic activities of leaf extracts from two selected cultivars in comparison with wild-growing plants have been evaluated. HPLC-DAD/ESI-ToF-MS analysis revealed the presence of phenolic acids and flavonoids with chlorogenic acid and rutin being the dominant compounds in the cultivated plants, whereas rutin and kaempeferol-3-O-rutinoside for wild growing ones. In particular, cv. Erma contained the highest amount of chlorogenic acid and showed a strong tyrosinase-inhibitory effect. Staphylococcus aureus, Listeria monocytogenes, and Penicillium funiculosum were the most sensitive strains when exposed to extracts from cultivated plants. Antimutagenic activity was evaluated by Ames' test. The tested extracts provided high protection against mutagenicity induced by 2-anthramine (2-AA) to Salmonella typhimurium strains TA 98 and TA 100 (max. inhibition (%) 88% and 74.2%, respectively). Overall, Goji leaves are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.
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Phenolic profiles, antioxidant activities and enzyme inhibitory effects of an Algerian medicinal plant (Clematis cirrhosa L.)
Scopus
Havuzumuzda Open Access 25 atıf almış
Clematis cirrhosa L. an Algerian medicinal plant widely distributed in the North of Algeria. It is used in traditional medicine for rheumatism pain and as diuretic agent. In this study methanol and hydromethanol extracts of Clematis cirrhosa were subjected to several tests in order to determine their phenolic compositions, antioxidant activities, and their enzyme inhibitory activities. The total polyphenols and total flavonoids contents were evaluated using colorimetric methods. The antioxidant activities were measured by various methods, namely free radical (DPPH. and ABTS.+) scavenging tests, and ion reducing capacity assays (FRAP and CUPRAC). The two extracts were examined for their inhibition activities of α-amylase, α-glucosidase, cholinesterase, tyrosinase enzymes. Also, the phenolic profiles of the studied extracts were determined by HPLC/DAD. The results showed that methanol extract had the highest antioxidant capacity with a highest amount of total phenol (84.05±0.8 mg GAE/g) and total flavonoid (114.60 ± 2.42 µg QE/g). The two extracts had noticeable enzyme inhibitory effects towards tyrosinase, AChE, BChE, α-glycosidase and α-amylase. HPLC/DAD analysis revealed that the studied extracts were rich on benzoic acid, hydroxybenzoic acid, catechin, caffeic acid, and epicatechin.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Selçuk Üniversitesi
Selçuklu, Turkey
Université Badji Mokhtar - Annaba
Annaba, Algeria