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Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
Scopus
Open Access Toplam 182 atıf DOI
Goji (Lycium barbarum L.) leaves are emphasized as a functional tea or as dietary supplements. The phenolic compound profile, antioxidant, enzyme inhibitory, antimicrobial, and antimutagenic activities of leaf extracts from two selected cultivars in comparison with wild-growing plants have been evaluated. HPLC-DAD/ESI-ToF-MS analysis revealed the presence of phenolic acids and flavonoids with chlorogenic acid and rutin being the dominant compounds in the cultivated plants, whereas rutin and kaempeferol-3-O-rutinoside for wild growing ones. In particular, cv. Erma contained the highest amount of chlorogenic acid and showed a strong tyrosinase-inhibitory effect. Staphylococcus aureus, Listeria monocytogenes, and Penicillium funiculosum were the most sensitive strains when exposed to extracts from cultivated plants. Antimutagenic activity was evaluated by Ames' test. The tested extracts provided high protection against mutagenicity induced by 2-anthramine (2-AA) to Salmonella typhimurium strains TA 98 and TA 100 (max. inhibition (%) 88% and 74.2%, respectively). Overall, Goji leaves are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.
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Effects of extraction and drying techniques on the chemical composition and biological activities of Helichrysum italicum
Scopus
Havuzumuzda 20 atıf almış
In this study, the impact of different drying processes, conventional air-drying (S) and freeze drying (F), on biochemical composition and biological activity of extracts of Helichrysum italicum obtained by using traditional (maceration- MAC) and modern extraction techniques (ultrasound (UAE) and microwave (MAE) extraction) was screened. The total phenol content of examined extracts yield in range of 49.7–119.77 mg GAE/g, while total flavonoid content yield in range of 2.92–21.96 mg RE/g. Qualitative and quantitative analysis showed that rutin and quercetin are the components that are present in all extracts in high amount. Radical scavenging activity was confirmed by DPPH and ABTS tests, and reduction ability by FRAP and CUPRAC tests. Total antioxidant activity and chelating ability of the extracts were also confirmed. While ethanol extracts (E) exhibited higher anti-acetylcholinesterase, water extracts (W) were more active in butyrylcholinesterase enzyme inhibition. All extracts were found to inhibit tyrosinase, amylase and glucosidase enzymes. Microwave extraction technique was found to be better extraction technique and air-drying more effective drying process for isolation of phenolic compounds and biological activity of Helichrysum italicum.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Selçuk Üniversitesi
Selçuklu, Turkey
University of Kragujevac
Kragujevac, Serbia
University of Novi Sad
Novi Sad, Serbia