Kurumun Atıf Alan Makalesi
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Bioactive compounds in seaweeds: An overview of their biological properties and safety
Scopus
Toplam 188 atıf DOI
Seaweeds are among the significant currently exploited marine plant resources which are gaining full applications in culinary, cosmetic, pharmaceutical, and biotechnological processes. Much attention has been devoted to seaweeds based on their proven health benefits and is considered as a rich source of structurally different bioactive metabolites for the discovery of novel functional food-based pharmacophores/drugs. Nonetheless, there is still a dearth of updated compilation and analysis of the in-depth pharmacological activities of these compounds. This review, therefore, aims to provide a piece of up-to-date detailed information on the major compounds isolated from various seaweed species together with their in-vitro and in-vivo biological properties. These compounds were found to possess broad pharmacological properties and inhibitory enzyme activities against critical enzymes involved in the aetiology of noncommunicable diseases. However, their toxicity, clinical efficacy, mechanisms of action, and interaction with conventional foods, are still less explored and require more attention in future studies.
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Atıf Yapan Yayın
HPLC-UV analysis of phenolic compounds and biological activities of Padina pavonica and Zanardinia typus marine macroalgae species
Scopus
Havuzumuzda Open Access 7 atıf almış
The marine macroalgae species are recognized as the food of the future with excellent bioactive properties. This study aimed to investigate phenolic compounds; cytotoxic, antibacterial, and antioxidant activities; total phenolic (TPC) and flavonoid (TFC) contents of the methanol, ethanol, and water extracts of Padina pavonica (PP) and Zanardinia typus (ZT). To the best of our knowledge, this is the first report in which ZT was evaluated in terms of phenolic content, antioxidant, antibacterial, and cytotoxic activities. The HPLC analysis allowed the identification of five phenolic compounds containing rutin (0.31 ± 0.04 – 3.00 ± 0.21 ppm) in all extracts and trans-p-coumaric acid (0.15 ± 0.02 – 3.95 ± 0.02 ppm) in MPP, EPP, MZT, EZT, WZT as the major compounds. TPC and TFC of the extracts were calculated as 11.78 ± 0.75 – 76.78 ± 0.54 µg GAEs/mg extract and 6.78 ± 0.17 – 29.50 ± 2.23 µg QEs/mg extract, respectively. The highest cytotoxicity was observed in EZT (CC50:132.3 ± 22.4 µg/mL) against MCF-7 and MZT (CC50: 91.4 ± 20.9 µg/mL) against MIA PaCa-2. Among the studied extracts, EPP showed the best antibacterial activity against all test pathogens. Also, EPP indicated superior antibacterial activity against Plesiomonas shigelloides (MIC: 1.25 mg/mL) and Staphylococcus aureus (MIC: 1.25 mg/mL). EZT displayed the highest antioxidant activity in DPPH• (IC50: 49.03 ± 0.28 µg/mL), CUPRAC (A0.50: 15.20 ± 0.14 µg/mL), and ABTS•+ (IC50: 18.86 ± 0.74 µg/mL) assays. The results approved that P. pavonica and Z. typus marine macroalgae species could be valued as natural sources of bioactive agents for food and pharmacology applications.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
Akdeniz Üniversitesi
Antalya, Turkey
Karamanoğlu Mehmetbey Üniversitesi
Karaman, Turkey
Konya Technical University
Konya, Turkey
Necmettin Erbakan Üniversitesi
Meram, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey