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Pharmacological insights into the multifaceted biological properties of quinic acid
Scopus
Toplam 200 atıf DOI
Quinic acid is a cyclohexanecarboxylic acid contained in the extracts of several parts of medicinal plants including Haematocarpus validus, Hypericum empetrifolium, Achillea pseudoaleppica, Rumex nepalensis, Phagnalon saxatile subsp. saxatile, Coffea arabica, Ziziphus lotus L, and Artemisia annua L … etc. Currently, in vitro and in vivo pharmacological studies showed that quinic acid exhibits various biological activities, such as antioxidant, antidiabetic, anticancer activity, antimicrobial, antiviral, aging, protective, anti-nociceptive and analgesic effects. Indeed, QA possesses an important antibacterial effect which could be explained by the fact that this molecule modules the functions of ribosomes and the synthesis of aminoacyl-tRNAs, modifications the levels of glycerophospholipids and fatty acids and disruption of the oxidative phosphorylation pathway thereby causing interference with membrane fluidity. The antidiabetic activity of AQ is achieved by stimulation of insulin secretion via the mobilization of Ca2+ from intracellular reserves and the increase in the NAD(P)H/NAD(P)+ ratio. Its anticancer effect is through the promotion of apoptosis, inhibition of activator protein 1 (AP-1) and signaling pathways involving protein kinase C (PKC) and certain mitogen-activated protein kinases (MAPKs), resulting in the downregulation of matrix metallopeptidase 9 (MMP-9) expression. Therefore, this review describes the main research work carried out on the biological properties of AQ and the mechanism of action underlying some of these effects, as well as the investigations of the main pharmacokinetic studies.
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Experimental and theoretical exploration of biological activities of different extracts of Equisetum arvense: Enzyme inhibition, DFT, molecular docking and molecular dynamics analyses
Scopus
Havuzumuzda 1 atıf almış
In this study, the antioxidant and enzyme inhibition capacities of acetone, ethanol, and water extracts of E. arvense were comprehensively investigated using both experimental and theoretical approaches. The phytochemical constituents of the extracts were characterized by a validated LC-MS/MS method, which identified 53 bioactive molecules commonly found in medicinal plants, including prominent compounds such as Isoquercitrin, Quinic acid, Acacetin, Aconitic acid, Caffeic acid, and Protocatechuic acid. Among the tested extracts, acetone exhibited the highest levels of phenolic and flavonoid contents, and accordingly demonstrated the strongest antioxidant activity as evaluated by DPPH, ABTS, CUPRAC, FRAP, and other assays. Enzyme inhibition studies showed the strongest effect for the ethanol extract in cholinesterase inhibition tests. Similarly, the greatest inhibition of tyrosinase was observed with the ethanol extract. To elucidate the molecular basis of these bioactivities, dominant compounds were subjected to density functional theory (DFT) calculations and molecular docking simulations against key enzymes. Theoretical results confirmed that Isoquercitrin and Acacetin possess favorable electronic and binding properties, suggesting their role in the observed bioactivities. These findings highlight E. arvense as a promising natural source of multifunctional phytochemicals with potential applications in managing oxidative stress and metabolic disorders.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Cumhuriyet Üniversitesi
Sivas, Turkey
Dicle Üniversitesi
Diyarbakir, Turkey
Ege Üniversitesi
Izmir, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey