Kurumun Atıf Alan Makalesi
Atıf Alan Yayın
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes
Scopus
Toplam 222 atıf DOI
The interest of medicinal plants as therapeutic agents against diseases such as Alzheimer, skin disorders and diabetes mellitus is growing. In order to investigate the influence of Haplophyllum myrtifolium, four solvent extracts (petroleum ether, ethyl acetate, methanol and water) were screened for antioxidant potentials, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glycosidase activity. Antioxidant effects were elucidated by different assays including free radical scavenging (ABTS, DPPH and NO assay), reducing power (FRAP and CUPRAC), phosphomolybdenum, β-carotene/linoleic acid system and metal chelating. Total phenolic, flavonoid, flavanol, tannin and saponin contents in these extracts were also calculated. Generally, ethyl acetate extract showed the strongest antioxidant activity in these extracts. This activity may be related to a good total phenolic content. The total phenolic contents of these extracts ranged from 32.32 to 52.50. mg GAEs/g extract. Except for water extract, all extracts showed good inhibitory activities on cholinesterase, tyrosinase, amylase and glycosidase. Apolar extracts (petroleum ether and ethyl acetate) were more potent as enzyme inhibitors in comparison to polar extracts (methanol and water). These findings reveal that H. myrtifolium could be used a source of natural compounds for the management of oxidative damage, Alzheimer, skin disorders and diabetes mellitus. © 2014 Elsevier B.V.
Atıf Kaynağı
Atıf Yapan Yayın
Multicomponent pattern and biological activities of seven Asphodeline taxa: Potential sources of natural-functional ingredients for bioactive formulations
Scopus
Havuzumuzda Open Access 73 atıf almış
The current study was carried out to evaluate multicomponent pattern, biological and enzymatic activities of seven Asphodeline taxa root extracts as useful ingredients, due to the fact that these plants are commonly used as traditional food supplements in Turkish regions. The extracts were characterized for free anthraquinones and phenolics to obtain a specific chemical fingerprint useful for quality control. These analyzes were coupled to biological and enzymatic activities in order to obtain comprehensive information of the natural product. Free anthraquinones and phenolics were determined using validated HPLC-PDA methods. Antioxidant properties were determined by different procedures including free radical scavenging, reducing power, phosphomolybdenum and metal chelating assays. Ames assay was performed to evaluate mutagenic/antimutagenic properties. Enzyme inhibitory activities were tested against cholinesterase, tyrosinase, a-amylase and a-glucosidase. From the herein reported results, Asphodeline could be valuable for the production of bioactive products or food supplements for cosmetic and pharmaceutical industries. List of abbreviations: ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); AChE: acetylcholinesterase; ADD: A. damascena subsp. damascena; ADG: A. damascena subsp. gigantea; ADO: A. damascena subsp. ovoidea; ADR: A. damascena subsp. rugosa; APR: A. prismatocarpa; ATT: A. tenuior subsp. tenuiflora var. tenuiflora; ATU: A. turcica; BChE: butyrylcholinesterase; CUPRAC: cupric ion reducing; DPPH: 2,2-diphenyl-1-picrylhydrazyl; en: endemic; FDA: Food and Drug Administration; FRAP: ferric ion reducing antioxidant power; GAE: gallic acid equivalents; HPLC-PDA: high performance liquid chromatography - photodiode array detector; RE: rutin equivalents; TE: trolox equivalents.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Interuniversity Consortium of Structural and Systems Biology
Rome, Italy
Medical University of Sofia
Sofia, Bulgaria
Selçuk Üniversitesi
Selçuklu, Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti, Italy