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Atıf Alan Yayın
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes
Scopus
Toplam 222 atıf DOI
The interest of medicinal plants as therapeutic agents against diseases such as Alzheimer, skin disorders and diabetes mellitus is growing. In order to investigate the influence of Haplophyllum myrtifolium, four solvent extracts (petroleum ether, ethyl acetate, methanol and water) were screened for antioxidant potentials, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glycosidase activity. Antioxidant effects were elucidated by different assays including free radical scavenging (ABTS, DPPH and NO assay), reducing power (FRAP and CUPRAC), phosphomolybdenum, β-carotene/linoleic acid system and metal chelating. Total phenolic, flavonoid, flavanol, tannin and saponin contents in these extracts were also calculated. Generally, ethyl acetate extract showed the strongest antioxidant activity in these extracts. This activity may be related to a good total phenolic content. The total phenolic contents of these extracts ranged from 32.32 to 52.50. mg GAEs/g extract. Except for water extract, all extracts showed good inhibitory activities on cholinesterase, tyrosinase, amylase and glycosidase. Apolar extracts (petroleum ether and ethyl acetate) were more potent as enzyme inhibitors in comparison to polar extracts (methanol and water). These findings reveal that H. myrtifolium could be used a source of natural compounds for the management of oxidative damage, Alzheimer, skin disorders and diabetes mellitus. © 2014 Elsevier B.V.
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Atıf Yapan Yayın
In-depth study of phytochemical composition, antioxidant activity, enzyme inhibitory and antiproliferative properties of Achillea filipendulina: a good candidate for designing biologically-active food products
Scopus
Havuzumuzda 19 atıf almış
Achillea species (Asteraceae) are important medicinal foods widely used as traditional medicine, herbal tea, and food additives. In the present study, the chemical composition, antioxidant, cytotoxicity, and enzyme inhibitory activities (α-amylase, α-glucosidase, cholinesterase, and tyrosinase) of the essential oils (EOs) and ethanolic (EtOH) extracts from flowers and leaves of Achillea filipendulina were investigated. The EOs were characterized by the presence of 35 and 38 volatile constituents, representing 98.88% and 97.26% of the flowers and leaves oils, respectively. Chrysanthenyl acetate (19.11% and 16.26%), 1,8-cineole (17.18% and 12.01%), borneol (9.70% and 7.66%), and α-pinene (9.60% and 8.77%) were identified as the major compounds. Phenolics profiling showed 11 phenolic acid and flavonoids are presented in this herb flower and leaves EtOH extracts of which chlorogenic acid (214.95 and 154.54 mg/100 g extract), cinnamic acid (116.67 and 90.41 mg/100 g extract), and apigenin (204.89 and 228.28 mg/100 g extract) were the major ingredients. Moreover, the extracts contained significant amounts of total phenolics, flavonoids, tannins, and saponin compounds. All samples showed moderate to high inhibitory effects against key enzyme linked to Alzheimer’s and diabetes diseases. Furthermore, the extracts exhibited promising antityrosinase activity. Evaluation of antiproliferative activity exerted that flower of the plant had the highest effect on MCF-7 and Hep-G2 cell lines, while the plant essential oil didn’t have significant effect. Overall, our findings indicated that A. filipendulina has great potential for designing novel industrial formulations including pharmaceuticals and cosmeceuticals.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Imam Khomeini International University
Qazvin, Iran
Maragheh University of Medical Sciences
Maragheh, Iran
Selçuk Üniversitesi
Selçuklu, Turkey
Tabriz University of Medical Sciences
Tabriz, Iran