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A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes
Scopus
Toplam 222 atıf DOI
The interest of medicinal plants as therapeutic agents against diseases such as Alzheimer, skin disorders and diabetes mellitus is growing. In order to investigate the influence of Haplophyllum myrtifolium, four solvent extracts (petroleum ether, ethyl acetate, methanol and water) were screened for antioxidant potentials, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glycosidase activity. Antioxidant effects were elucidated by different assays including free radical scavenging (ABTS, DPPH and NO assay), reducing power (FRAP and CUPRAC), phosphomolybdenum, β-carotene/linoleic acid system and metal chelating. Total phenolic, flavonoid, flavanol, tannin and saponin contents in these extracts were also calculated. Generally, ethyl acetate extract showed the strongest antioxidant activity in these extracts. This activity may be related to a good total phenolic content. The total phenolic contents of these extracts ranged from 32.32 to 52.50. mg GAEs/g extract. Except for water extract, all extracts showed good inhibitory activities on cholinesterase, tyrosinase, amylase and glycosidase. Apolar extracts (petroleum ether and ethyl acetate) were more potent as enzyme inhibitors in comparison to polar extracts (methanol and water). These findings reveal that H. myrtifolium could be used a source of natural compounds for the management of oxidative damage, Alzheimer, skin disorders and diabetes mellitus. © 2014 Elsevier B.V.
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Evaluating Total Phenolic Content, Antioxidant Activity, High Molecular Weight Glutenin Subunits (HMW-GS), and Grain Yield Parameters of Cultivated Wheat and Hybrids
Scopus
Havuzumuzda 2 atıf almış
This study was conducted to assess the high molecular weight glutenin subunits (HMW-GS), yield, total phenolic content (TPC), and antioxidant capacity using five assays: free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), and phosphomolybdenum. Wheat species, old cultivar, landrace, and hybrid wheat genotypes were compared with adaptive modern bread and durum wheat cultivars. Under rainfed conditions, high grain yield was particularly obtained from T. turanicum, T. polonicum, and T. compactum wheat species, as T. spelta, T. compactum, T. turanicum, T. turgidum, and T. polonicum were better performed to grain yield under irrigated conditions. In the study, the wheat genotypes, T. petropavlovskyi, T. spelta, T. sphaerococcum, T. compactum, Yektay 406, Ak 702, Köse 220/39, and wheat hybrids were found to have the HMW-GS 2 + 12 in Glu-D1 in relation to low quality. The Yellowstone wheat cultivar carried high-quality alleles together for 1 in Glu-A1 and 5 + 10 in Glu-D1. The study exhibited that T. monococcum (einkorn), T. spelta (spelt), T. dicoccum (emmer), and Yektay 406 (old cultivar) for better antioxidant capacity were displayed together in the same cluster of the dendrogram constructed by DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum assay results. In addition, significant correlations were observed between TPC, ABTS, CUPRAC, FRAP, and phosphomolybdenum. The study suggested that ancient wheat species superior to the investigated characteristics had antioxidants beneficial for healthy nutrition and may also be used in the improvement of cultivars with high yield and quality.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Selçuk Üniversitesi
Selçuklu, Turkey
Transitional Zone Agricultural Research Institute
Eskisehir, Turkey