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A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes
Scopus
Toplam 222 atıf DOI
The interest of medicinal plants as therapeutic agents against diseases such as Alzheimer, skin disorders and diabetes mellitus is growing. In order to investigate the influence of Haplophyllum myrtifolium, four solvent extracts (petroleum ether, ethyl acetate, methanol and water) were screened for antioxidant potentials, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glycosidase activity. Antioxidant effects were elucidated by different assays including free radical scavenging (ABTS, DPPH and NO assay), reducing power (FRAP and CUPRAC), phosphomolybdenum, β-carotene/linoleic acid system and metal chelating. Total phenolic, flavonoid, flavanol, tannin and saponin contents in these extracts were also calculated. Generally, ethyl acetate extract showed the strongest antioxidant activity in these extracts. This activity may be related to a good total phenolic content. The total phenolic contents of these extracts ranged from 32.32 to 52.50. mg GAEs/g extract. Except for water extract, all extracts showed good inhibitory activities on cholinesterase, tyrosinase, amylase and glycosidase. Apolar extracts (petroleum ether and ethyl acetate) were more potent as enzyme inhibitors in comparison to polar extracts (methanol and water). These findings reveal that H. myrtifolium could be used a source of natural compounds for the management of oxidative damage, Alzheimer, skin disorders and diabetes mellitus. © 2014 Elsevier B.V.
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Multifunctional Bioactivities of Button Mushroom Agaricus bisporus (Agaricomycetes) Extracts: From Phenolic Content to Antiviral Action against HRSV and HSV-1
Scopus
Havuzumuzda
Agaricus bisporus is one of the widely cultivated edible mushrooms and plays an important role in human nutrition. Therefore, revealing the biological and pharmacological properties of the mushroom will contribute to a more conscious approach towards its consumption. This study aimed to comprehensively investigate and compare the biological activities of extracts obtained from A. bisporus by Soxhlet ethanol and aqueous extraction (SEE and SEW, respectively) and ultrasonic-assisted ethanol and aqueous extraction (UAE and UAW). The phenolic composition was determined by HPLC analysis, among 21 standards; quercetin was found to be the most prominent. Different techniques were used to determine antioxidant activity, including phosphomolybden, radical scavenging (DPPH and ABTS), power reducing (FRAP and CUPRAC), and iron chelation experiments. The total phenolic content and total flavonoid content were tested. It was generally determined that ethanol extracts were rich in phenolic compounds, had higher total phenolic content, and exhibited higher antioxidant activity. Enzyme inhibitory activities were tested using different methods, including determination of acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase activities. Significant enzyme inhibitory activity was seen in SEE against all enzymes. The antiviral activity of non-toxic extract concentrations against HRSV and HSV-1 viruses was investigated. All tested extracts demonstrated anti-HRSV activity, with the highest activity observed in the SEW extract [selective index (SI) = 135.90]. Anti-HSV-1 activity was detected only in UAW extract (SI = 85.86). According to the antiviral activity results, it was seen that the extracts showed higher anti-HRSV activity. These results emphasise the health benefits of A. bisporus as well as its role in nutrition.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Afyonkarahisar Health Sciences University
Afyonkarahisar, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey