Kurumun Atıf Alan Makalesi
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Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils
Scopus
Toplam 225 atıf DOI
Essential oils (EOs) from Origanum vulgare subsp. vulgare (OVV) and O. vulgare subsp. hirtum (OVH) were evaluated for antioxidant activities (DPPH, ABTS, FRAP, CUPRAC, β-carotene/linoleic acid, phosphomolybdenum and metal chelating), antimicrobial and inhibitory properties against acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase. Thymol and linalool were identified as major component in OVV and OVH essential oils, respectively. O. vulgare subsp. vulgare exhibited a strong free radical scavenging, reducing power, antimicrobial and acetylcholinesterase, butrylcholinesterase, α-amylase and α-glucosidase inhibitory activity. Interestingly, OVH possess a significant metal chelating and tyrosinase inhibitory activities. The EOs of both species exhibited moderate antibacterial and antifungal activities. The MIC values of the EOs ranged from 85.3 to 426.7. μg/mL. O. vulgare subsp. vulgare showed higher activity against Sarcina lutea with the lowest MIC (85.3. μg/mL), whereas OVH indicated strong activity for Candida albicans with MIC value of 85.3. μg/mL. The data suggest that the Origanum EOs could be used as valuable new natural agents with functional properties for food and pharmacology industries.
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Atıf Yapan Yayın
UHPLC-LTQ OrbiTrap MS analysis and biological properties of Origanum vulgare subsp. viridulum obtained by different extraction methods
Scopus
Havuzumuzda 53 atıf almış
The growing awareness on implications related to the use of harsh chemicals and non-sustainable extraction methods of bioactive compounds from plants is causing a paradigm shift towards a more eco-friendly approach. The present study sets out to investigate the possible variation in the antioxidant, mutagenic/antimutagenic, antimicrobial, and enzyme inhibitory properties of Origanum vulgare subsp. viridulum extracts obtained using conventional, namely, maceration and Soxhlet extraction, and non-conventional, namely, ultrasound-assisted (UAE), microwave-assisted (MAE), and accelerated solvent extraction (ASE), techniques. Also, chemical characterization of these extracts were performed via ultrahigh-performance liquid chromatography and mass spectrometry (UHPLC-LTQ OrbiTrap MS) technique. A total of 58 polyphenols were identified in the tested extracts. Highest phenolic content was obtained from ASE (186.63 mg gallic acid equivalent [GAE]/g) and MAE (170.90 mg GAE/g) extracts. Maceration extract (18.89 mg rutin equivalent [RE]/g) showed highest flavonoid content. ASE extract showed highest activity in the DPPH (359.45 mg Trolox equivalent [TE]/g), ABTS (679.63 mg TE/g), FRAP (1433.94 mg TE/g), and CUPRAC (1685.72 mg TE/g) assays. In terms of enzyme inhibition, the UAE extract showed highest activity against acetyl cholinesterase (4.55 mg galantamine equivalent [GALAE]/g), butyryl cholinesterase (6.12 mg GALAE/g), and tyrosinase (173.87 mg kojic acid equivalent [KAE]/g) compared with the other extracts. The extracts exhibited significant antimutagenic and antimicrobial properties. Data collected from this study support the use of ASE and UAE in the extraction of bioactive compounds from Origanum vulgare subsp. viridulum aerial parts.
Atıf Yapan Makale Bilgileri
Kurumlar (7)
Duy Tan University
Da Nang, Viet Nam
Institute of Food Technology in Novi Sad
Novi Sad, Serbia
Marmara Üniversitesi
Istanbul, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey
University of Belgrade
Belgrade, Serbia
University of Mauritius
Reduit, Mauritius
University of Novi Sad
Novi Sad, Serbia