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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species
Scopus
Toplam 223 atıf DOI
The methanol and aqueous extracts of three endemic Centaurea species (C. polypodiifolia var pseudobehen, C. pyrrhoblephara and C. antalyense) were investigated for their antioxidant and cholinesterase inhibitory activities. The antioxidant activities of these extracts were evaluated by in vitro models including, phosphomolybdenum assay, free radical scavenging assays (DPPH and ABTS), β-carotene/linoleic acid test system, metal chelating assay, FRAP assay, ferric and cupric reducing power. Cholinesterase inhibitory activities were examined using Ellman's colorimetric method. Total phenol, flavonoid, and saponin contents were also measured. Among the six Centaurea extracts evaluated, the highest antioxidant abilities were obtained from C. polypodiifolia var pseudobehen. Methanolic extracts from C. polypodiifolia var pseudobehen and C. antalyense had a noticeable inhibition towards AChE and BChE. These findings suggest that Centaurea species could be an anticholinesterase agent and antioxidant resource in some industries, such as food, pharmacology, and cosmetics. © 2013 Elsevier Ltd.
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Screening for antioxidant and antimutagenic properties of extracts from centaurea pterocaula as well as their enzyme inhibitory potentials
Scopus
Havuzumuzda 15 atıf almış
The purpose of this study was to evaluate the antioxidant capacities, mutagenic/antimutagenic propeties and enzyme inhibitory effects of three extracts (ethyl acetate, methanol and water) of Centaurea pterocaula. The antioxidant properties were investigated using in vitro antioxidant methods such as radical scavenging (DPPH assay), reducing power (FRAP and CUPRAC assays), phosphomolybdenum and metal chelating activity. Enzyme inhibitory effects were tested aganist cholinesterase, tyrosinase, amylase and glucosidase. Ames test was used to show mutagenic/antimutagenic properties of these extracts. Methanol extract had the strongest free radical scavenging (31.06 mgTE/g extract) and reducing power abilities (66.95 mgTE/g extract for CUPRAC and 51.03 mgTE/g extract for FRAP). Also, ethyl acetate extract exhibited the strongest effect on the tested enzymes (except for glucosidase). Total phenolic and flavonoid contents were found to be 15.77-25.22 mg GAE/g extract and 0.67-31.44 mg RE/g extract, respectively. The mutagenicity was not seen for all extracts tested, while it was determined that some samples had significant antimutagenicity. In the condition of presence of S9 mix, ethyl acetate and methanol extracts revealed excellent antimutagenic activity (92% and 92%) at a dose of 5000 μg/plate against 2-aminoflourene (2-AF) for TA98 strain. According to the results of the present study, C. pterocaula can be considered as a potential source for developing new nutraceuticals or pharmaceuticals.
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Kurumlar (1)
Selçuk Üniversitesi
Selçuklu, Turkey