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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species
Scopus
Toplam 223 atıf DOI
The methanol and aqueous extracts of three endemic Centaurea species (C. polypodiifolia var pseudobehen, C. pyrrhoblephara and C. antalyense) were investigated for their antioxidant and cholinesterase inhibitory activities. The antioxidant activities of these extracts were evaluated by in vitro models including, phosphomolybdenum assay, free radical scavenging assays (DPPH and ABTS), β-carotene/linoleic acid test system, metal chelating assay, FRAP assay, ferric and cupric reducing power. Cholinesterase inhibitory activities were examined using Ellman's colorimetric method. Total phenol, flavonoid, and saponin contents were also measured. Among the six Centaurea extracts evaluated, the highest antioxidant abilities were obtained from C. polypodiifolia var pseudobehen. Methanolic extracts from C. polypodiifolia var pseudobehen and C. antalyense had a noticeable inhibition towards AChE and BChE. These findings suggest that Centaurea species could be an anticholinesterase agent and antioxidant resource in some industries, such as food, pharmacology, and cosmetics. © 2013 Elsevier Ltd.
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Chemical and biological approaches on nine fruit tree leaves collected from the Mediterranean region of Turkey
Scopus
Havuzumuzda 57 atıf almış
The antioxidant and enzyme inhibitory activities of two extracts [methanolic and water] of nine different fruit tree leaves were assessed. The antioxidant activity of leaves was determined by ABTS (2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)), DPPH (1,1-diphenyl-2-picrylhydrazyl radical), CUPRAC (cupric ion reducing antioxidant capacity), and FRAP (ferric reducing antioxidant power)assays. The enzyme inhibitory activity was evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase. Individual phenolic components were detected using HPLC-DAD (high performance liquid chromatography-diode array detector) technique. Chlorogenic acid was the most abundant compounds in the leaves. Total phenolic and flavonoid contents were determined as 22.24-274.50 milligram gallic acid equivalents (mgGAE/g) and 4.93-46.99 milligram rutin equivalents (mgRE/g), respectively. A higher antioxidant and enzyme inhibitory activity was observed in pomegranate and carob extract as compared to other leaves. This study suggested that the leaves may be beneficial for preparing novel functional food ingredients.
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Kurumlar (1)
Selçuk Üniversitesi
Selçuklu, Turkey