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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species
Scopus
Toplam 223 atıf DOI
The methanol and aqueous extracts of three endemic Centaurea species (C. polypodiifolia var pseudobehen, C. pyrrhoblephara and C. antalyense) were investigated for their antioxidant and cholinesterase inhibitory activities. The antioxidant activities of these extracts were evaluated by in vitro models including, phosphomolybdenum assay, free radical scavenging assays (DPPH and ABTS), β-carotene/linoleic acid test system, metal chelating assay, FRAP assay, ferric and cupric reducing power. Cholinesterase inhibitory activities were examined using Ellman's colorimetric method. Total phenol, flavonoid, and saponin contents were also measured. Among the six Centaurea extracts evaluated, the highest antioxidant abilities were obtained from C. polypodiifolia var pseudobehen. Methanolic extracts from C. polypodiifolia var pseudobehen and C. antalyense had a noticeable inhibition towards AChE and BChE. These findings suggest that Centaurea species could be an anticholinesterase agent and antioxidant resource in some industries, such as food, pharmacology, and cosmetics. © 2013 Elsevier Ltd.
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Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approach
Scopus
Havuzumuzda 67 atıf almış
The increasing therapeutic use of plant essential oil (EO) in aromatherapy has urged scientists to investigate into its biological potency. We report the phytochemical composition of the EO of Aegle marmelos (L.) Corrêa using GC–MS analysis, together with its pharmacological properties (antibacterial, antioxidant, and enzyme inhibitory properties). Molecular docking of the major identified compounds against tyrosinase and α-glucosidase was also performed. The EO displayed the highest total antioxidant potential in the phosphomolybdenum assay (24.70 mmol TE/g sample), but showed mild scavenging (DPPH = 0.03 mmol TE/g sample), and reducing effect (CUPRAC = 0.54 mmol TE/g sample, FRAP = 0.21 mmol TE/g sample). Moreover, the EO of A. marmelos showed the greatest inhibitory property against tyrosinase 53.68 (mg KAE/g sample) and good inhibitory effect on α-glucosidase (39.08 mmol ACAE/g sample) compared with α-amylase (0.19 mmol ACAE/g sample). In addition, the EO exhibited moderate AChE inhibition (2.75 mg GALAE/g sample) and BChE inhibition (4.93 mg GALAE/g sample). Disc diffusion assay revealed that S. aureus (Zone of inhibition (ZOI) = 21.4 mm) was most susceptible to the EO followed by C. diphtheriae (ZOI = 17.2 mm) while the lowest MIC value was observed against B. cereus and C. diphtheriae (MIC = 125 μg/ml). The EO of A. marmelos was abundant in limonene (74.9%) followed by β-phellandrene (4.4%), p-cymene (4.2%), and β-caryophyllene (2.0%). Humulene and cryptone exhibited higher docking score after docking to tyrosinase while the best docking scores observed against α-glucosidase was found for humulene and carveol. The EO of A. marmelos showed promising inhibitory activities against vital enzymes related to diabetes, neurological, and skin disorders, and mild antioxidant ability, thus highlighting the quenching abilities of surplus reactive oxygen species related to these disorders. It is predicted that the results obtained will stimulate further research to probe into the therapeutic properties of A. marmelos.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Selçuk Üniversitesi
Selçuklu, Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti, Italy
University of Mauritius
Reduit, Mauritius