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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Influence of drying process on chemical composition, antioxidant and enzyme-inhibitory activity of Helichrysum italicum essential oils
Scopus
Havuzumuzda 8 atıf almış
Introduction: Helichrysum italicum (Roth) G. Don, also known as immortelle, is a medicinal plant from the Mediterranean region. It is widely used in traditional medicine as an antiinflammatory and antimicrobial agent. Owing to the rich composition and beneficial effects of its essential oil, it is not only attractive for use in traditional medicine but also in pharmacy, medicine, and cosmetology. This study examines the chemical composition and biological activity of the essential oil obtained from fresh and dried immortelle, as well as the influence of the drying technique on the oil's quality. Methods: To isolate the essential oil from immortelle, fresh, naturally dried, and freeze-dried aerial parts of the plant were subjected to the hydrodistillation. The essential oils obtained were then characterized chemically and biologically. Results: GC-MS analysis showed that α-pinene (29.77%) was the dominant compound in the oil isolated from the fresh plant, while α-muurolene was the most abundant compound in samples obtained from dried plants (ranging from 30.03% to 20.15%). The essential oil isolated from the fresh plant exhibited the highest antioxidant activity, whereas the oil obtained from freeze-dried plants showed the lowest potential. In terms of amylase inhibition, similar activity was observed, while the situation was opposite for tyrosinase inhibition. Conclusion: This research provides a detailed insight into the influence of the drying technique on the chemical composition and biological activity of immortelle essential oil. The study demonstrates the potential of using immortelle essential oil as a natural agent for diabetes and hyperpigmentation control.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Institute of General and Physical Chemistry Serbia
Belgrade, Serbia
Selçuk Üniversitesi
Selçuklu, Turkey
University of Novi Sad
Novi Sad, Serbia