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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Elucidation of chemical compounds in different extracts of two Lavandula taxa and their biological potentials: Walking with versatile agents on the road from nature to functional applications
Scopus
Havuzumuzda 12 atıf almış
Due to their health-promoting and nutraceutical properties, lavenders are frequently employed in the food and pharmaceutical industries. Here, we focused on investigate the chemical profile of hexane, MeOH, and water extracts of leaf, flower, and root of L. pedunculata and L. stoechas and to assess their antioxidant, enzyme inhibitory, and antibacterial properties. The highest total polyphenolic and flavonoids contents were recorded from the water and MeOH extracts of the leaf and flower of L. stoechas, respectively. Our HPLC/MS/MS analysis detected over 90 secondary metabolites, consisting of both known and novel terpenoids, polyphenols, flavonoids, and their derivative. Water leaf extract of L. stoechas displayed significantly (p < 0.05) the highest antiradical, Cu2+ and Fe3+ reducing capacity while hexane extract of the leaf and MeOH extract of the flower of L. pedunculata revealed the best metal chelating ability and total antioxidant activity respectively. The hexane extract of the leaf of L. pedunculata exerted the highest acetylcholinesterase and tyrosinase inhibition activity, whereas the hexane extracts from L. stoechas leaf and L. pedunculata root recorded the highest ability to inhibit the butyrylcholinesterase and ⍺-amylase enzymes respectively. The water extracts of the leaf of the two species, besides the hexane extract of the leaf of L. pedunculata exerted the best inhibition effect against the α-glucosidase. The sensitivities of Gram-positive and Gram-negative bacteria species against different extracts at two different concentrations were tested based on agar well diffusion assay. According to the result, we found that the n-hexane extract of L. stoechas-flowers showed the highest antibacterial activity. In conclusion, the results suggest that both Lavandula species have promising potential as sources of bioactive agents for various industrial applications.
Atıf Yapan Makale Bilgileri
Kurumlar (6)
Balikesir Üniversitesi
Balikesir, Turkey
Gdańsk University of Technology
Gdansk, Poland
Khartoum University
Khartoum, Sudan
Necmettin Erbakan Üniversitesi
Meram, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey
University of Nyíregyháza
Nyíregyháza, Hungary