Kurumun Atıf Alan Makalesi
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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Atıf Yapan Yayın
In vitro research to evaluate the antioxidant effects, inhibiting enzymes, methicillin-resistant Staphylococcus aureus strains of Terminalia catappa extracts
Scopus
Havuzumuzda Open Access 8 atıf almış
Aim: Contribute to the well-being of the Ivorian population through scientific proof of the use of Terminalia cattapa leaves extracts in traditional medicine. Methodology: The antioxidative effect of aqueous, water-alcoholic, ethyl acetate and hexane derivatives of Terminalia catappa leaves was measured by six tests: DPPH (2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)), FRAP (ferric ion reducing antioxidant power), PPBD (phosphomolybdenum), CUPRAC (cupric ion reducing antioxidant capacity) and MCA (metal chelating activity). The inhibition of the activity of five enzymes (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase) was also determined. In addition, the broadcast method was used to evaluate impact of the samples on methicillin-resistant Staphylococcus aureus (MRSA) strains. Results: Highest antioxidant capacity was obtained in the ethanolic sample for DPPH, ABTS, FRAP and PPBD tests. Ethyl acetate sample produced the best CUPRAC and MCA tests. Among inhibitory effect of samples on the five enzymes, aqueous sample showed the strongest anti-acetylCholynesterase and anti-butyrylCholynesterase activity. Best anti-tyrosinase and anti-amylase activity were obtained with the ethanolic sample. Hexane sample obtained the best anti-glucosidase activity while ethanolic and aqueous samples obtained none. All extracts showed no activity on the MRSA strains tested. Conclusion: The chemical compounds present in Terminalia cattapa leaves extracts would not be responsible for the use made in traditional medicine against infections.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Dicle Üniversitesi
Diyarbakir, Turkey
Institut Pasteur de Cote-d'Ivoire
Abidjan, Cote d'Ivoire
Selçuk Üniversitesi
Selçuklu, Turkey
Université de Cocody-Abidjan
Abidjan, Cote d'Ivoire