Kurumun Atıf Alan Makalesi
Atıf Alan Yayın
Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Atıf Yapan Yayın
Integration of chemical characterization, biological activities, and network pharmacology of different extracts from Syzygium rowlandii
Scopus
Havuzumuzda 5 atıf almış
The leaves and stem barks of Syzygium rowlandii, were considered as sources of biologically active compounds. Using the ultrasound-assisted extraction with different solvents, we obtained three types of extracts (ethyl acetate (EA), methanol (MeOH), and water), which were characterized by NMR and LC-MS. Quinic acid, myricetin-7-O-glucuronide, myricetin-3-O-rhamnoside, and oleanolic acid were the most abundant compounds. Bioassays were performed showing antioxidant and enzyme inhibitory properties. Molecular docking revealed the binding properties of some plant constituents against tested enzymes were evaluated allowing to obtain crucial information that combined chemical composition, bioassay results and in silico studies. Results showed that myricetin-7-O-glucuronide had good binding potential for tyrosinase, amylase, and glucosidase partially explaining the observed bioactivity. Network pharmacology also predicted desirable and potent targets for the isolated compounds in various disease pathways. Our findings suggest that S. rowlandii can be a promising source of biologically active compounds and our approach can be useful for designing functional applications, such as pharmaceuticals, nutraceuticals, or cosmeceuticals.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
Faculté des Sciences Rabat
Rabat, Morocco
İstanbul Arel Üniversitesi
Istanbul, Turkey
Saveetha Medical College and Hospital
Chennai, India
Selçuk Üniversitesi
Selçuklu, Turkey
Università degli Studi di Padova
Padua, Italy