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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Tissue-specific metabolic and phenolic profiling of onion (Allium cepa L.) in response to nutrient deficiency
Scopus
Havuzumuzda Open Access 3 atıf almış
Nutrient availability plays a crucial role in plant metabolism, but its tissue-specific effects in onions (Allium cepa L.) remain poorly understood. This study aimed to elucidate the hierarchical effects of reduced nutrient supply on the metabolic profile of onion tissues, i.e., leaves, roots, and bulbs, using a multivariate metabolomics approach. Onion cultures were established in a hydroponic system, treated with Hoagland's solutions at 100 % as the control (C), and diluted solutions at 12.5 % (H12), 25 % (H25), and 50 % (H50). The metabolic signatures of onions subjected to nutrient depletion were reported by a metabolomics approach based on ultra-high-pressure liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UHPLC/QTOF-MS). Among the treatments, H25 notably enhanced antioxidant capacity and enzyme inhibitory activities linked to neuroprotective and antidiabetic potential, particularly in bulbs. This study provides insights into optimizing nutrient management for enhanced crop quality and functionality, providing deeper insights into tissue-specific metabolic differences and the mechanisms underlying metabolite accumulation, whether through increased biosynthesis or translocation between tissues.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Selçuk Üniversitesi
Selçuklu, Turkey
Universidad de Murcia
Murcia, Spain
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza, Italy