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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Chemical profile of essential oil from Pimenta racemosa leaves, antioxidant potential, and its enzyme inhibitory properties
Scopus
Havuzumuzda Open Access 4 atıf almış
Pimenta racemosa var. recemosa (Mill.) J. W. Moore is an aromatic plant belonging to the family Myrtaceae, native to Venezuela, Puerto Rico, and Jamaica and well-known for its traditional and medicinal uses. Our study was designated to explore the chemical composition of essential oil isolated from P. racemosa leaves growing in Egypt via Gas Chromatography/Mass Spectrometry (GC-MS) analysis, alongside investigation of its antioxidant properties and enzyme inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-glucosidase, and α-amylase. The GC-MS analysis of the leaf oil revealed the presence of fourteen compounds (99.76%), predominated by eugenol (70.87%), β-myrcene (12.88%) and D-limonene (8.35%). The oil demonstrated the highest antioxidant capability in ferric ion-reducing antioxidant power (FRAP; 1506.62 mg TE/g), followed by 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS; 1346.85 mg TE/g), 1,1-diphenyl-2-picrylhydrazyl (DPPH; 1032.83 mg TE/g) and cupric-reducing antioxidant capacity (CUPRAC; 1001.03 mg TE/g). Further, it showed a metal chelating ability (MCA) of 25.63 mg EDTAE/, and phosphomolybdenum (PBD) activity of 209.59 mmol TE/g. The oil displayed significant AChE and BChE inhibitory activities, with values of 1.96 mg GALAE/g and 1.42 mg GALAE/g, respectively. Additionally, it exhibited a moderate level of tyrosinase inhibitory activity (38.83 mg KAE/g) and a significantly higher α-glucosidase inhibitory activity (2.38 mmol ACAE/g) than α-amylase (0.08 mmol ACAE/g). Consequently, the leaf oil of Pimenta racemosa could be used as adjuvant therapy for management of oxidative stress-related conditions and chronic diseases such as Alzheimer’s, diabetes mellitus, and skin pigmentation. However, further toxicological, in vivo and clinical studies are recommended.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Faculty of Pharmacy, Ain Shams University
Cairo, Egypt
Selçuk Üniversitesi
Selçuklu, Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti, Italy