Kurumun Atıf Alan Makalesi
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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Phytochemistry diversity and antioxidant activities of Cladostephus spongiosus (Hudson) C. Agardh
Scopus
Havuzumuzda 3 atıf almış
Cladostephus spongiosus (Hudson) C. Agardh is a cosmopolitan brown alga, yet its phytochemical profile and biological potential remain scarcely investigated. This study provides the first comprehensive assessment of C. spongiosus collected from the Moroccan Strait of Gibraltar (Fardioua coastline). Five extracts were evaluated for total phenolic, flavonoid, and tannin contents, and chemically characterized for bioactive compounds, and assessed for antioxidant properties. Nine compounds were identified, several reported here for the first time in C. spongiosus. Among the extracts the ethanolic and the dichloromethane extracts displayed the highest total phenolic and flavonoid contents, with the dichloromethane also exhibiting the strongest ABTS radical scavenging activity (318.07 ± 5.3 mg/TE g dry extract). The methanol extract demonstrated the strongest anti-DPPH potential. The aqueous extract contained the highest tannin content and showed the greatest metal chelating capacity, as well as the strongest reducing power in the FRAP assay (31.37 ± 0.20 mg/TE g dry extract). The hexane extract displayed notable reducing power activity in the CUPRAC assay and was the most potent in terms of total antioxidant capacity. Overall, our findings highlight C. spongiosus as promising source of antioxidants and bioactive compounds, underscoring its nutraceutical potential.
Atıf Yapan Makale Bilgileri
Kurumlar (7)
College of Pharmacy
Riyadh, Saudi Arabia
Faculté de Médecine et de Pharmacie de Rabat
Rabat, Morocco
Faculté des Sciences Rabat
Rabat, Morocco
Princess Nourah Bint Abdulrahman University
Riyadh, Saudi Arabia
Selçuk Üniversitesi
Selçuklu, Turkey
Universitas Airlangga
Surabaya, Indonesia
Université Abdelmalek Essaadi
Tetouan, Morocco