Kurumun Atıf Alan Makalesi
Atıf Alan Yayın
Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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Atıf Yapan Yayın
Design, synthesis and biological activities of gold-conjugated piperazine-dithiocarbamates: Antimicrobial and tyrosinase inhibitory activities
Scopus
Havuzumuzda
In this study, a set of piperazine-derived dithiocarbamate ligands (1a-6a) and the corresponding gold nanoparticle (NP)–conjugated derivatives (AuLNPs) (1b-6b) were synthesized and characterized by 1H and 13C NMR, MALDI-TOF, FTIR. The bioactive potential of the synthesized products was also screened for antimicrobial, antioxidant and tyrosinase inhibition activities. The free ligands showed mild to moderate activity against three fungi and six bacteria strains, but association with gold led to marked improvements in the biological activities of some derivatives. The AuLNPs, especially, exhibited enhanced effectiveness against both Gram-positive as well as Candida species. Derivative 2b was the most effective compound in all compounds tested, showing the strongest tyrosinase inhibiting activity (IC50 = 0.51 ± 0.01 mg/mL) and it was among the substances that yielded the best results in antioxidant tests (DPPH, ABTS, CUPRAC). The computational findings generally supported the experimental results, suggesting that smaller energy band gaps and moderate softness may contribute to the observed activity. These findings show that gold nanoparticle conjugation plays an important role in modulating the biological activity of the ligands.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
İstinye Üniversitesi
Istanbul, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey
University of Health Sciences
Istanbul, Turkey