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In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca
Scopus
Toplam 432 atıf DOI
The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts obtained from the herb P. thuringiaca were analysed for antioxidant and enzyme inhibitory activities. The UHPLC-DAD-MS3 hyphenated techniques reported herein allow for the identification of phytoconstituents. The analyses showed the presence of flavonoids and ellagitannins as major components. Furthermore, the data demonstrated that the analysed extracts revealed a high total antioxidant capacity in the phosphomolybdenum assay. The free radical scavenging activity of the extracts was evaluated using DPPH and ABTS assays. The reducing power activity of P. thuringiaca was also determined by FRAP and CUPRAC assays, as well as metal chelating activity. In addition, the total extracts and the different fractions of P. thuringiaca revealed potent inhibitory activities against α-amylase and α-glucosidase, AChE, tyrosinase and lipase. Surprisingly, no activity against BChE was shown. P. thuringiaca could be a valuable natural source of antioxidants with interesting inhibitory actions against the key enzymes involved in several human diseases, and could represent a valid starting point for the development of new treatment and management strategies, including its use as a food supplement.
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Atıf Yapan Yayın
NMR metabolic profiling and biological activities of different extracts from a Turkish herbal tea-Clinopodium nepeta subsp. glandulosum
Scopus
Havuzumuzda 3 atıf almış
Clinopodium nepeta subsp. glandulosum (Req.) Govaerts (Lamiaceae), is traditionally used as antispasmodic, diaphoretic, stimulant, and tonic medicinal herbs and as mint-like spice used in various culinary recipes. Nonetheless, there is still a dearth of studies to validate its biological properties. The total phenolic and flavonoid contents, scavenging activity of DPPH and ABTS radicals, ferric reducing antioxidant power (FRAP), total antioxidant via phosphomolybdenum assay, metal ion chelating capacity of different extracts (n-hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water and water) of C. nepeta were determined. The water extract contained the highest phenolic contents (51.47 ± 0.62 mg GAE/g) and ethanol/water extract yielded largest amount of flavonoid contents (43.86 ± 0.63 mg RE/g). The DPPH free radical scavenging activity of the extracts was in the order of ethanol/water > water > ethanol > ethyl acetate > dichloromethane > n-hexane. The enzyme inhibition of the different extracts was also investigated. Ethanol/Water extract demonstrated the highest AChE inhibitory capacity (2.66 mg GALAE/g) while ethyl acetate extract revealed high BChE inhibitory activity (3.29 mg GALAE/g). Exhaustive 2D-NMR investigation has revealed the presence of acacetin derivatives, ursolic acid along with and 2,4-di-t-butylphenol. These findings revealed that extracts of C. nepeta could be used as a promising therapeutic agent against free radicals, brain enzymes including AChE and BChE and in the treatment of hyperpigmentation as a skin whitening ingredient as well as in the treatment and management of diabetes. However, further studies are required to determine the safety profiles of these extracts.
Atıf Yapan Makale Bilgileri
Kurumlar (7)
Jazan University
Jizan, Saudi Arabia
Marmara Üniversitesi
Istanbul, Turkey
North-West University
Potchefstroom, South Africa
Saveetha Dental College And Hospitals
Chennai, India
Selçuk Üniversitesi
Selçuklu, Turkey
Università degli Studi della Campania Luigi Vanvitelli
Naples, Italy
University of Mauritius
Reduit, Mauritius