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In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca
Scopus
Toplam 432 atıf DOI
The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts obtained from the herb P. thuringiaca were analysed for antioxidant and enzyme inhibitory activities. The UHPLC-DAD-MS3 hyphenated techniques reported herein allow for the identification of phytoconstituents. The analyses showed the presence of flavonoids and ellagitannins as major components. Furthermore, the data demonstrated that the analysed extracts revealed a high total antioxidant capacity in the phosphomolybdenum assay. The free radical scavenging activity of the extracts was evaluated using DPPH and ABTS assays. The reducing power activity of P. thuringiaca was also determined by FRAP and CUPRAC assays, as well as metal chelating activity. In addition, the total extracts and the different fractions of P. thuringiaca revealed potent inhibitory activities against α-amylase and α-glucosidase, AChE, tyrosinase and lipase. Surprisingly, no activity against BChE was shown. P. thuringiaca could be a valuable natural source of antioxidants with interesting inhibitory actions against the key enzymes involved in several human diseases, and could represent a valid starting point for the development of new treatment and management strategies, including its use as a food supplement.
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Atıf Yapan Yayın
Nutraceutical Potential of Oilseeds and By-Products (Cakes) of Three Underutilized Malvaceae Trees Grown in Sudan
Scopus
Havuzumuzda Open Access
The nutraceutical potential of seed oils and cakes of Adansonia digitata, Grewia tenax, and Thespesia garckeana was evaluated by determining their chemical profile and examining their antioxidant and enzyme inhibitory properties. Oils of G. tenax and T. garckeana were rich in polyunsaturated fatty acids. The cake methanolic extract of T. garckeana revealed the highest antiradical (44.67 mg trolox equivalent (TE)/g extract) and metal chelating (26.38 mg EDTA equivalent/g extract) properties, while the oil of G. tenax displayed the highest Cu++ (180.62 mg TE/g extract) and Fe+++ (82.07 mg TE/g extract) reducing capacity. Pelargonidin and rutin were the dominant antioxidant compounds. The oil of A. digitata displayed the highest anti-acetylcholinesterase (2.44 mg galantamine equivalent (GALAE)/g extract) and butyrylcholinesterase (2.10 mg GALAE/g extract) activity, while its cake exhibited the best α-glucosidase inhibitory activity (1.46 acarbose equivalent (ACAE)/g extract). The cake of T. garckeana exerted the highest α-amylase inhibitory effect (0.71 mmol ACAE/g extract). The highest anti-tyrosinase activity (10.88 mg kojic acid equivalent/g extract) was recorded from the cake of G. tenax. These results indicated that these seeds could be a rich source of antioxidants that target diseases associated with oxidative stress, like diabetes and certain neurological disorders.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
İstanbul Medipol Üniversitesi
Istanbul, Turkey
Khartoum University
Khartoum, Sudan
Selçuk Üniversitesi
Selçuklu, Turkey
Sudan International University
Khartoum, Sudan
Université de Lorraine
Nancy, France