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In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca
Scopus
Toplam 432 atıf DOI
The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts obtained from the herb P. thuringiaca were analysed for antioxidant and enzyme inhibitory activities. The UHPLC-DAD-MS3 hyphenated techniques reported herein allow for the identification of phytoconstituents. The analyses showed the presence of flavonoids and ellagitannins as major components. Furthermore, the data demonstrated that the analysed extracts revealed a high total antioxidant capacity in the phosphomolybdenum assay. The free radical scavenging activity of the extracts was evaluated using DPPH and ABTS assays. The reducing power activity of P. thuringiaca was also determined by FRAP and CUPRAC assays, as well as metal chelating activity. In addition, the total extracts and the different fractions of P. thuringiaca revealed potent inhibitory activities against α-amylase and α-glucosidase, AChE, tyrosinase and lipase. Surprisingly, no activity against BChE was shown. P. thuringiaca could be a valuable natural source of antioxidants with interesting inhibitory actions against the key enzymes involved in several human diseases, and could represent a valid starting point for the development of new treatment and management strategies, including its use as a food supplement.
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Ultrasound-Assisted Extraction of Bioactive Compounds from Strawberry Pomace: Optimization and Bioactivity Assessment
Scopus
Havuzumuzda Open Access 3 atıf almış
The growing production of strawberry-based foods generates large quantities of pomace, a phenolic-rich by-product with high valorization potential. This study aimed to optimize ultrasound-assisted extraction (UAE) of strawberry pomace and to evaluate the bioactivity of the resulting extracts. The greenness assessment using the AGREEprep metric yielded a score of 0.68/1, confirming the environmental friendliness of the process. Under the optimized UAE conditions (20 min, 50 °C, solid-to-liquid ratio 1:20 g/mL), the extract exhibited the highest total phenolic (16.49 mg GAE/g) and flavonoid contents (2.10 mg RE/g). The optimized extract showed strong antioxidant activity, with DPPH, ABTS, CUPRAC, and FRAP values of 32.70, 46.76, 57.29, and 38.90 mg TE/g, respectively. Enzyme inhibition was particularly pronounced against tyrosinase (55.45 mg KAE/g), while moderate inhibition of acetylcholinesterase and butyrylcholinesterase was also observed. Artificial neural network (ANN) modeling demonstrated excellent predictive performance (R2 > 0.99) and enabled effective optimization of extraction parameters. These findings confirm UAE as an efficient and sustainable approach for strawberry pomace valorization and highlight ANN-based optimization as a robust tool for developing multifunctional bioactive extracts for food, nutraceutical, and pharmaceutical applications.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
Selçuk Üniversitesi
Selçuklu, Turkey
University of Belgrade
Belgrade, Serbia
University of Novi Sad
Novi Sad, Serbia