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In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca
Scopus
Toplam 432 atıf DOI
The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts obtained from the herb P. thuringiaca were analysed for antioxidant and enzyme inhibitory activities. The UHPLC-DAD-MS3 hyphenated techniques reported herein allow for the identification of phytoconstituents. The analyses showed the presence of flavonoids and ellagitannins as major components. Furthermore, the data demonstrated that the analysed extracts revealed a high total antioxidant capacity in the phosphomolybdenum assay. The free radical scavenging activity of the extracts was evaluated using DPPH and ABTS assays. The reducing power activity of P. thuringiaca was also determined by FRAP and CUPRAC assays, as well as metal chelating activity. In addition, the total extracts and the different fractions of P. thuringiaca revealed potent inhibitory activities against α-amylase and α-glucosidase, AChE, tyrosinase and lipase. Surprisingly, no activity against BChE was shown. P. thuringiaca could be a valuable natural source of antioxidants with interesting inhibitory actions against the key enzymes involved in several human diseases, and could represent a valid starting point for the development of new treatment and management strategies, including its use as a food supplement.
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Exogenous Syringic Acid Mitigates Arsenic Toxicity in Lettuce Plants: A Physiological, Antioxidant, and Metabolomics Investigation
Scopus
Havuzumuzda
Arsenic (As) contamination in agricultural water and soil poses a growing threat to leafy vegetable safety, with lettuce being particularly vulnerable due to its high water content and direct consumption without processing. This study investigated the capacity of exogenous syringic acid (SyA) to mitigate As-induced toxicity in lettuce plants, integrating physiological, biochemical, and untargeted metabolomics approaches. Arsenic significantly reduced plant biomass (31% and 53% in fresh and dry weight), impaired stomatal conductance, and suppressed net CO2 assimilation. However, the SyA application, particularly at 10 μM, significantly restored biomass, photosynthetic performance, and redox homeostasis under As stress. Notably, SyA enhanced antioxidant capacity, as reflected by elevated FRAP and CUPRAC activities and increased accumulation of the phenolic compounds. Untargeted metabolomics revealed that As exposure broadly reprogrammed secondary metabolism, including activation of the phenylpropanoid and shikimate pathways with notable accumulation of flavonoid glycosides and alkaloids, consistent with a shift toward oxidative defense. Conversely, SyA at 500 μM exerted phytotoxic effects even under nonstress conditions, confirming a biphasic, concentration-dependent mode of action with a critical threshold between 250 and 500 μM. The findings suggest that an optimized concentration of SyA can act as a metabolic modulator, fine-tuning the plant responses to As by boosting the antioxidant defense system.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Consiglio Nazionale delle Ricerche
Rome, Italy
Necmettin Erbakan Üniversitesi
Meram, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza, Italy